Bioanalytical tools and methods for precise and quantitative interrogation of biological systems.
Rationale & Projects
Life is fundamentally characterized by order, with an orchestra of biochemical reactions running in the compartments within, on and between cells. These reactions have to occur at the right place and at the right time so as to manifest healthy functioning. We work on new methodologies with the aim to provide greater insight into such interactions at different length and time-scales. A particular focus currently is on precise tumor profiling.
open space microfluidics
Reconfigurable microfluidics
Surface assays
Tumor profiling
Featured Articles
Mapping Spatial Genetic Landscapes
L. Voith von Voithenberg, A. Kashyap, et al., Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows, Small , 2021.
Micro-scale technologies propel biology
I. Pereiro, J. Aubert, and G. V. Kaigala., Micro-scale technologies propel biology and medicine, Biomicrofluidics , 2021.
Biointegrated Fluidic Milling
D. Widerker, F. Paratore, M. Bercovici., and G. V. Kaigala, Biointegrated Fluidic Milling, Advanced Materials Technologies , 2021.
Rapid microIHC
R. Lovchik, D. Taylor, and G. V. Kaigala, Rapid micro-immunohistochemistry, Microsystems & Nanoengineering , 2020.
P. Mathur, A. F. Khartchenko, A. F., A. deMello, and G. V. Kaigala,, Open space diffusive filter for simultaneous species retrieval and separation, Analytical Chemistry , 2020.
I. Pereiro, A. F. Khartchenko and G. V. Kaigala, Shake it or flow it: Mass transport and kinetics in surface bioassays using agitation and microfluidics, Analytical Chemistry , 2020.
Collaborations
We work with several academia and industrial partners in collaborative projects. An excellent example of a collaboration with academia is with Prof. Moran Bercovici from Technion, and some of this joint work was done within the framework of a EU-funded EID project – Virtual Vials. Other active academic collaborations are with ETH-Z and EPFL. We further highly value working with the medical/clinical community and the current active collaborations are with the University Hospital Zurich, Bern and Frankfurt.