Bioanalytical tools and methods for precise and quantitative interrogation of biological systems.
Rationale & Projects
Life is fundamentally characterized by order, with an orchestra of biochemical reactions running in the compartments within, on and between cells. These reactions have to occur at the right place and at the right time so as to manifest healthy functioning. We work on new methodologies with the aim to provide greater insight into such interactions at different length and time-scales.
open space microfluidics
Reconfigurable microfluidics
Surface assays
Tumor profiling
Featured Articles
V. Bacheva, F. Paratore, S. Rubin, G. V. Kaigala and M. Bercovici, Diffusion-based separation using bidirectional electroosmotic flow,“Angewandte Chemie International Edition, 2020.
D. Taylor, and G. V. Kaigala, Reconfigurable Microfluidics: Real-time Shaping of Virtual Channels through Hydrodynamic Forces, Lab on a Chip, 2020.
N. Ostromohov, B. Rofman, M. Bercovici, and G. V. Kaigala, Electrokinetic Scanning Probe, Small, 2020.
L. V. Voithenberg, D. Huber, A. F. Khartchenko, P. Schraml, and G. V. Kaigala, Spatially multiplexed RNA in situ hybridization to reveal tumor heterogeneity, Nucleic Acids Research, 2019.
X. F. van Kooten, L. F.T. Petrini, A. Kashyap, L. V. von Voithenberg, M. Bercovici and G. V. Kaigala, “Spatially resolved genetic analysis of tissue sections enabled by microscale flow confinement retrieval and isotachophoretic purification,” Angewandte Chemie International Edition, Volume 58, Issue 43, 15259-15262, 2019.
I. Pereiro, J. F. Cors, S. Pané, B. J. Nelson, G. V. Kaigala, “Underpinning transport phenomena for biopatterning” Chemical Society Reviews, 48, 1236-1254,2019.
Collaborations
We work with academia and industrial partners in collaborative projects. An excellent example of a collaboration with academia is with Prof. Moran Bercovici from Technion, and some of this joint work was done within the framework of a EU-funded EID project – Virtual Vials. Other active academic collaborations are with ETH-Z, EPFL and the University Hospital Zurich and Bern.